Meaningful change: defining the interpretability of changes in endpoints derived from interactive and mHealth technologies in healthcare and clinical research

Immersive, interactive and mHealth technologies are increasingly being used in clinical research, healthcare and rehabilitation solutions. Leveraging technology solutions to derive new and novel clinical outcome measures is important to the ongoing assessment of clinical interventions. While demonstrating statistically significant changes is an important element of intervention assessment, understanding whether changes detected reflect changes of a magnitude that are considered meaningful to patients is equally important. We describe methodologies used to determine meaningful change and recommend that these techniques are routinely included in the development and testing of clinical assessment and rehabilitation technology solutions

Graphene-like nano-sheets/36° LiTaO3 surface acoustic wave hydrogen gas sensor

Presented is the material and gas sensing properties of graphene-like nano-sheets deposited on 36deg YX lithium tantalate (LiTaO3) surface acoustic wave (SAW) transducers. The graphene-like nano-sheets were characterized via scanning electron microscopy (SEM), atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). The graphenelike nano-sheet/SAW sensors were exposed to different concentrations of hydrogen (H2) gas in a synthetic air at room temperature. The developed sensors exhibit good sensitivity towards low concentrations of H2 in ambient conditions, as well as excellent dynamic performance towards H2 at room temperature

Performance and Radiation Testing of a Low-Noise Switched Capacitor Array for the CMS Endcap Muon System.

The 16-channel, 96-cell per channel switched capacitor array ( SCA) ASIC developed at UC Davis for the cathode readout of the cathode strip chambers ( CSC) in the CMS endcap muon system is ready for production. For the final full-sized prototype, the Address Decoder was re-designed and LVDS receivers were incorporated into the chip package. Under precision testing, the chip exhibits excellent linearity within the 1V design range and very low cell-to-cell pedestal variation. Monitored samples of the production design were subjected to exposure to a 63.3 MeV proton beam. The performance of chips after exposures up to 100 krad was within tolerances of an unexposed part

A wearable headset for monitoring electromyography responses within spinal surgery

Purpose: This research examines an approach for enhancing the efficiency of spinal surgery utilising the technological capabilities and design functionalities of wearable headsets, in this case Google Glass. The aim was to improve the efficiency of the selective dorsal rhizotomy neurosurgical procedure initially through the use of Glass via an innovative approach to information design for an intraoperative monitoring display. Methods Utilising primary and secondary research methods the development of a new electromyography response display for a wearable headset was undertaken. Results: Testing proved that Glass was fit for purpose and that the new intraoperative monitor design provided an example platform for the innovative intraoperative monitoring display; however, alternative wearable headsets such as the Microsoft HoloLens could also be equally viable. Conclusion: The new display design combined with the appropriate wearable technology could greatly benefit the selective dorsal rhizotomy procedure

Relations Between Timing Features and Colors in the X-Ray Binary 4U 0614+09

We study the correlations between timing and X-ray spectral properties in the low mass X-ray binary 4U 0614+09 using a large (265-ks) data set obtained with the Rossi X-ray Timing Explorer. We find strong quasi-periodic oscillations (QPOs) of the X-ray flux, like the kilohertz QPOs in many other X-ray binaries with accreting neutron stars, with frequencies ranging from 1329 Hz down to 418 Hz and, perhaps, as low as 153 Hz. We report the highest frequency QPO yet from any low mass X-ray binary at 1329+-4 Hz, which has implications for neutron star structure. This QPO has a 3.5-sigma single-trial significance, for an estimated 40 trials the significance is 2.4-sigma. Besides the kilohertz QPOs, the Fourier power spectra show four additional components: high frequency noise (HFN), described by a broken power-law with a break frequency between 0.7 and 45 Hz, very low frequency noise (VLFN), which is fitted as a power-law below 1 Hz, and two broad Lorentzians with centroid frequencies varying from 6 to 38 Hz and 97 to 158 Hz, respectively. We find strong correlations between the frequencies of the kilohertz QPOs, the frequency of the 6 to 38 Hz broad Lorentzian, the break frequency of the HFN, the strength of both the HFN and the VLFN and the position of the source in the hard X-ray color vs. intensity diagram. The frequency of the 97 to 158 Hz Lorentzian does not correlate with these parameters. We also find that the relation between power density and break frequency of the HFN is similar to that established for black hole candidates in the low state. We suggest that the changing mass accretion rate is responsible for the correlated changes in all these parameters.Comment: ApJ, referee

Density saturation and the decrease of the normalised width of the multiplicity distribution in high energy pp collisions

It is experimentally observed that the width of the KNO multiplicity distribution --or the negative binomial parameter 1/k-- for pp collisions, in the energy region 10 to 1800 GeV, is an increasing function of the energy. We argue that in models with parton or string saturation such trend will necessary change: at some energy the distribution will start to become narrower. In the framework of percolating strings, we have estimated the change to occur at an energy of the order of 5--10 TeV.Comment: 10 pages, 4 figures, uses elsart and amsmath; comparison with some other models was added; version accepted by PL

Efficiency of nanoparticle reinforcement using finite element analysis of titanium alloy mandible plate

Nanoparticles in the form nanotubes and nanoplatelets have been compared for von Mises stresses by using them as low-composition reinforcements in titanium alloy–based mandible plate for different compositions and orientations. A finite element model has been designed to reconstruct a fractured human mandible with a titanium alloy mandible plate. A 500 N compressive force was applied on the mandible, and stress distribution across the plate sections was analysed for aligned two-dimensional random and three-dimensional random orientations for both tubes and platelets. Carbon material as graphene has been used for tube and platelet in the form of nanotubes and nanoplatelets, respectively. Using properties of graphene as the filler in titanium alloy plate, for both nanoplatelets and nanotubes, the stresses reduced between 5% and 25% for nanoplatelets and nanotubes graphene–titanium composite plates in comparison to non-reinforced plates, at critically stressed sections. Nanotubes exhibited stress reduction of nearly 23.4% for aligned configurations, while nanoplatelets exhibited stress reduction up to 21.2% for two-dimensional and three-dinemsional random configurations in comparison to non-reinforced titanium plates. Hence, it has been suggested that nanotubes exhibited superior mechanical reinforcement potential beyond that of aligned nanoplatelets, while nanoplatelets provided enhanced mechanical reinforcements for random configurations. Therefore, for biomedical implant applications nanocomposite materials can be designed with the same dimensional form but with lower compositions of filler materials by simply manipulating the appropriate orientations

The geographies of access to enterprise finance: the case of the West Midlands, UK

The geographies of access to enterprise finance: the case of the West Midlands, UK, Regional Studies. Whilst there is a long history of credit rationing to small and medium-sized enterprises (SMEs) in the UK, the financial crisis has seen banks retreat further from lending to viable SMEs due to a reassessment of risk and lack of available capital. In so doing, the credit crunch is thought to be creating new geographies of financial exclusion. This paper explores the financial inclusion of enterprise through community development finance institutions (CDFIs) which provide loan finance to firms at the commercial margins in the West Midlands, UK. The paper concludes that CDFIs could partially address the financial exclusion of enterprise as an additional, alternative source of finance to that of mainstream banks

A Quasi-Model-Independent Search for New Physics at Large Transverse Momentum

We apply a quasi-model-independent strategy ("Sleuth") to search for new high p_T physics in approximately 100 pb^-1 of ppbar collisions at sqrt(s) = 1.8 TeV collected by the DZero experiment during 1992-1996 at the Fermilab Tevatron. Over thirty-two e mu X, W+jets-like, Z+jets-like, and 3(lepton/photon)X exclusive final states are systematically analyzed for hints of physics beyond the standard model. Simultaneous sensitivity to a variety of models predicting new phenomena at the electroweak scale is demonstrated by testing the method on a particular signature in each set of final states. No evidence of new high p_T physics is observed in the course of this search, and we find that 89% of an ensemble of hypothetical similar experimental runs would have produced a final state with a candidate signal more interesting than the most interesting observed in these data.Comment: 28 pages, 17 figures. Submitted to Physical Review

Search for R-parity Violating Supersymmetry in Dimuon and Four-Jets Channel

We present results of a search for R-parity-violating decay of the neutralino chi_1^0, taken to be the Lightest Supersymmetric Particle. It is assumed that this decay proceeds through one of the lepton-number violating couplings lambda-prime_2jk (j=1,2; k=1,2,3). This search is based on 77.5 pb-1 of data, collected by the D0 experiment at the Fermilab Tevatron in ppbar collisions at a center of mass energy of 1.8 TeV in 1992-1995.Comment: 10 pages, 3 figure